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We’re depressed or anxious and we don’t feel like doing anything. Especially making love. So, we take antidepressants or other psych meds and we feel a lot better. But, because of the drugs, now we not only don’t feel like making love, it’s become a challenge to have a satisfying experience. Can anything be done about it?
For some people, antidepressants and other drugs for depression, bipolar or anxiety disorders improve their mood and their sex lives.
Others have trouble getting in the mood (loss of libido), have trouble performing (erectile dysfunction, or ED) or “can’t get no satisfaction” (anorgasmia, or difficulty in achieving orgasm}
No one really knows the statistics of sexual problems resulting from psych meds because patients don’t often talk to their doctors about it. So, although the product labeling on your drug may say its incidence is 0 to 14 percent, that’s probably underestimated. Some researchers would put it closer to 70 percent for some antidepressants.
What drugs can cause sexual problems?
Antidepressants
Sexual dysfunction has been reported with all classes of antidepressants: MAOIs, TCAs, SSRIs, SNRIs and newer antidepressants.
An SSRI (selective serotonin reuptake inhibitor) or SRI (non-selective serotonin reuptake inhibitor) antidepressant is often a culprit. Ninety percent of Americans taking antidepressants are taking one of these. Forty to seventy percent of those report treatment-related sexual dysfunction (SD). Reduced sexual desire is common, and studies have shown that at least 30-60 percent of men and women will experience some delay or difficulty in achieving orgasm during therapy with an SSRI. Men often experience erectile dysfunction and delayed ejaculation. The five SSRIs marketed in the United States are fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox) and citalopram (Celexa)
The incidence of SD varies widely among other classes of antidepressants. Effexor, an MAOI (monoamine oxidase inhibitor) has been shown to cause more sexual side effects than many other antidepressants. Wellbutrin, on the other hand, typically does not cause them, and in fact can help reduce symptoms caused by other drugs.
The tricyclic antidepressant Clomipramine (Anafranil) has been shown to have the greatest potential to cause delayed ejaculation. And, in one study, 70 to 96 percent of men and women taking this medication had trouble reaching orgasm or were unable to reach orgasm. Some men taking tricyclic antidepressants experience a loss of interest in sex or difficulty in maintaining an erection.
Mood stabilizers
Whether lithium used by itself causes sexual dysfunction is controversial. In one study, about a quarter of patients experienced lack of sexual interest. Difficulties in achieving and maintaining erections were reported in 14 percent. Lithium given in combination with benzodiazepines (anti-anxiety drugs) was associated with sexual dysfunction in about half of patients. Other researchers say lithium does not cause significant sexual problems.
Antipsychotics
At least 30-60 percent of men and women who take a typical antipsychotic drug with potent dopamine-blocking activity, including chlorpromazine (Thorazine), thioridazine (Mellaril), haloperidol (Haldol), fluphenazine (Prolixin), thiothixene (Navane) experience sexual problems. Decreased libido is the most common symptom. The newer atypical antipsychotic drugs, such as risperidone (Risperdol), quetiapine (Seroquel) and aripiprazole (Abilify), have much less dopamine-blocking effect and therefore, should be less likely to cause sexual side effects.
What can reduce sexual side effects?
Little research has been done on finding remedies for the sexual side effects of psychotropic medications. (Obviously, there aren’t enough researchers living with the problem.) Most doctors approach the problem by relying on “clinical wisdom, anecdotal reports, case reports, and open-label studies,” according to one report.
Possible options include decreasing the dosage, taking drug holidays, adding another medication, switching to an alternative medication without these effects, or waiting for tolerance to develop. And, just as important…romance.
Waiting it out
Waiting for adaptation may be the most frequently used approach, although studies have shown that remission from sexual side effects occurred in only 6 to 20 percent of patients.
Adjusting dosage
For some people, a reduction in the dosage in the guilty medication can reduce sexual problems, however it may result in a too-low therapeutic level, causing relapse or recurrence of depression.
Drug holiday
Taking a “holiday” from the medication is controversial, but has been shown to be an effective occasional remedy for sexual side effects. A patient occasionally skips their medication for two or three days to enjoy satisfactory sex for awhile, and then resumes treatment. But, a holiday of more than three days can risk relapse or serious discontinuation side effects.
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Many doctors warn against this idea. People with severe depression should not take drug holidays, says Dr. Dana Simpler, Mercy Medical Center, Baltimore, MD. And, it can be particularly dangerous for people with bipolar disorder.
“In general, in my view at least, and I know mine is widely shared, the very idea of any "drug holiday" is a terrible idea, says Jim Phelps, MD. “Mood stability is the goal, not the treatment of any particular episode. Rather, we want to prevent the next one.”
A drug holiday would work only for medications that maintain a therapeutic level for a few days, preventing the risk of relapse. Some drugs, such as fluoxetine (Prozac) can’t be eliminated from the body fast enough to reduce sexual side effects. NEVER take a drug holiday without thorough discussion with your doctor.
The two most effective management options are adding another drug and switching to an alternative.
Switching medications
If you’re taking an antidepressant that is likely to cause sexual problems, switching to one that isn’t, such as bupropion (Wellbutrin), nefazodone (Serzone), mirtazapine (Remeron) or perhaps citalopram (Celexa), may be a solution.
A risk of switching is that the new drug may not be as effective as the original.
Adding another medication
If you’re taking a drug that’s effectively treating your symptoms, but with sexual side effects, your doctor may consider adding another drug to manage the sexual dysfunction. Talk with your doctor about how they work, how they are taken, the symptoms they may relieve and their possible side effects.
The following drugs given in specific doses in combination with other psychotropics (especially antidepressants) have been found to reduce some sexual side effects for some patients.
- Amantadine (Symmetrel)
delayed ejaculation
- Bupropion (Wellbutrin)
improved desire and reduce problems with orgasm.
| ”Welllbutrin has helped about two-thirds of my patients with sexual side effects,” says Dr. Simpler. “It’s why, when treating depression, I often start with it.” |
Adding romance
Never underestimate the power of romantic gestures. If sex is a problem for you or your partner because of illness or medications, go a little above and beyond the every-day. Schedule together time at home or out. Look into each other’s eyes and really listen to what the other is saying. Candlelight and kisses, love notes and little surprises can be aphrodisiacs. (Here are some tips.)
Relax and be playful. And patient.
Related articles
Guide to psych meds
Take time out
More articles
Sources
* Jim, Phelps, MD, author of Why Am I Still Depressed? and publisher of PsychEducation
* Simpler, Dana, MD, internal medicine physician, Mercy Medical Center, Baltimore.
*
Bipolar disorder: A Guide for patients and Families, Francis Mark Mondimore, M.D.
*Clin Neuropharmacol. 1996 Dec;19(6):515-9.Links
Lithium and male sexual function in affective patients.
* Aizenberg D, Sigler M, Zemishlany Z, Weizman A. Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tikva, Israel.
*
Am J Psychiatry 1992; 149:801-805
Lithium, benzodiazepines, and sexual function in bipolar patients
AM Ghadirian, L Annable and MC Belanger, Allan Memorial Institute, Royal Victoria Hospital, Montreal, Que., Canada.
*NIMH
*USDA
*Department of Health & Human Services' (HHS) Agency for Healthcare Research and Quality (AHRQ).
*Options for Management of Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction Psychiatric Times August 01, 2007 Vol. 24 No. 9, H. George Nurnberg, MD
*
Management of and Counseling for Psychotropic Drug-Induced Sexual Dysfunction
Pharmacotherapy, July 1999
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