Living with depression, anxiety and bipolar disorder
June 2007
Home
Newsletter
Articles
Bookstore
Send page to a friend
Resources
About us
Community
Contact us
Site map

Of Like Minds is now Mood!

Sign up for our newsletter

Over 175 articles on:

Help support Mood --
$1/month for a year?

Donate by mail

Bookstore

©Moodletter, 2008
For people living with mood and anxiety disorders and others who want to be happier and healthier. Moodletter is a non-profit organization.


HONcode accreditation seal.
We comply with the HONcode standard for health trust worthy information:
verify here.

  
 
Multi-colored pills. Medication profile:
Lamictal® can smooth mood swings


 

Have you read these?

 

 

Many of those who live with bipolar disorder have found that Lamictal (Lamotrigine) helps to make moods swings fewer and further apart. And, prescribed with or without other mood stabilizers, it does it without adding to the weight gain typically found with the others.

Lamotrigine is an anticonvulsant that spreads out the episodes of depression and mania of bipolar disorder. It does not ease the actual symptoms of the depression or mania and therefore is usually taken in combination with other medications that do, such as lithium.

Although approved for bipolar I, Lamictal has been found to be effective as a treatment for depression and bipolar disorder of several kinds, especially bipolar II. Although it has not been found to be effective for treatment-resistant depression, doctors often prescribe it for treatment-resistant bipolar depression.

Lamictal, made by GlaxoSmithKline, was approved as a maintenance treatment for bipolar I in 1994.

How does it work?
Research has not determined exactly how lamotrigine works, but it appears to affect the general level of neuron excitability. Just how it does this remains unclear.

How do I take this medication?
Lamotrigine comes as a regular tablet and one that can be chewed or dissolved in liquid. Tablets come in 25-mg (white), 100-mg (peach), 150-mg (cream), and 200-mg (blue). For mood disorders, it is usually taken once a day. At the beginning of treatment, your doctor may direct you to take it every other day.

Follow directions carefully. If you forget a dose, take the missed dose as soon as you remember it. But if it is almost time for the next dose, skip the missed dose and continue your regular schedule. Do not take a double dose to make up for a missed one.

Do not stop taking lamotrigine without talking to your doctor who will probably decrease your dose gradually over two weeks or more at approximately 50% per week, the manufacturer's recommendation.

Caution
If you do stop taking lamotrigine for any reason, call your doctor immediately before you start taking it again. If you miss taking Lamictal for more than three to four days, you must start the treatment again with the same slow increase in dose as in the beginning or risk serious side effects.

There are other medications that have names similar to the brand name for lamotrigine. Be certain that you receive lamotrigine and not one of the similar medications each time you fill your prescription.

How fast does it work?
Many people taking Lamictal begin to feel improvement as the dosage is increased, often with some lifting of depression first, then stabilization of mood swings. It may take up to six weeks to reach the full therapeutic effect of this medication.

What do I need to tell my doctor
Tell your doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking, including contraceptives. Dosage adjustments will be necessary in most patients who start or stop estrogen-containing oral contraceptives while taking lamotrigine. Discuss any allergies you have.

Tell your doctor if

  • you have or have ever had heart, kidney, or liver disease or a blood disorder.
  • you are pregnant, plan to become pregnant, or are breast-feeding. Babies exposed to Lamictal during the first three months of pregnancy may have a higher chance of birth defects. If you become pregnant while taking it, call your doctor.
  • you are having surgery, including dental surgery, tell the doctor or dentist that you are taking lamotrigine.

What are possible side effects?
Like many medications, side effects may appear when first starting Lamictil or when your dosage is increased, but may go away after a short time.

The risk of non-serious rash is increased when the recommended initial dose and/or the rate of dose escalation of Lamictal is exceeded. In clinical studies, about 1 in 1,000 adults had severe, potentially life-threatening rash. The risk of rash may be increased by

  1. taking Lamictal in combination with valproate (Depakene or Depakote),
  2. exceeding the recommended initial dose of Lamictal, or
  3. exceeding the recommended dose escalation for lamotrigine.

 

 

Therefore, it is important that the dosing recommendations be followed closely. If you stopped taking Lamictal because of rash, you should not go back on the drug, unless you and your doctor decide the potential benefits clearly outweigh the risks.

Lamictal is not likely to case weight gain.

Tell your doctor if any of these or other side effects are severe or do not go away:

  • diarrhea or constipation
  • difficulty thinking or concentrating
  • dizziness
  • drowsiness
  • dry mouth
  • irritability
  • loss of balance or coordination
  • mood changes
  • nervousness
  • runny nose or cough
  • sleeping problems
  • stomach, back, or joint pain
  • vision problems

More serious side effects
If you experience any of these symptoms while you are taking lamotrigine, call your doctor immediately...

Drug interactions
Lamictal (lamotrigine) is chemically unrelated to existing anticonvulsive drugs. It can be effectively combined with lithium, bupropion (Wellbutrin) or olanzapine (Zyprexa®).

Lamotrigine is often combined with Depakote {Valproic acid), but with adjustments to its usual doses. Depakote significantly increases lamotrigine levels, and therefore, lamotrigine begun at half the usual dosage provides the same therapeutic effect as the recommended dose for someone not taking Depakote. So, someone taking Depakote might be instructed to begin taking Lamictal at 12.5 mg per day, while others might begin at 25 mg. The combination without this adjustment increases the risk of serious side effects.

How can I save on my prescriptions?
There is no generic version of Lamictal available now in the doses needed for treatment of mood disorders. However one is expected by the end of 2008, which will be offered at a significantly lower cost than the brand name drug.

Most insurance plans, including health maintenance organizations (HMOs), will cover treatment for depression and anxiety disorders. Check with your insurance company to find out.

If you don't have insurance, the Health and Human Services division of your county government may offer mental health care at a public mental health center that charges people according to how much they are able to pay. If you are on public assistance, you may be able to get care through your state Medicaid plan.

Many drug companies have prescription assistance programs for people who may have problems paying for their medicines. GlaxoSmithKline, maker of Lamictal, has an excellent patient assistance program for this medication. They also provide information about other resources that can help you.

Related articles

Sources
U.S. Food and Drug Administration
GlaxoSmithKline
MedlinePlus (National Institutes of Health: Department of Health & Human Services.)

More articles