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Recurrent major depressive episodes (> 3)

1. Early age of onset of major depressive episode (< age 25)
2. Family history of bipolar disorder in first-degree relative
3. Hyperthymic [over-active] personality (at baseline, nondepressed state)
4. Atypical depressive symptoms (DSM-IV criteria)
5. Brief major depressive episodes (on average, < 3 months)
6. Psychotic major depressive episodes
7. Postpartum depression
8. Antidepressant-induced mania or hypomania
9. Antidepressant "wear-off" (acute but not prophylactic response)
10. Lack of response to 3 adequate antidepressant treatment trials

Return to Bipolar II and the Bipolar Spectrum

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Page updated October 1, 2008